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The association between e-cigarette use and reported erectile dysfunction remained among men aged younger than 65 years with a normal BMI and without CVD, suggesting the association persists despite a relatively healthy population, the researchers wrote

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Interestingly, it has been shown that PHD2 has a higher affinity for -ketoglutarate and HIF-1 compared to PHD3, which preferentially (but not exclusively) hydroxylates HIF-2 [52, 53]

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